From Bench to Market: The Evolution of Chemical Synthesis Walter Cabri

ISBN: 9780198503842

Published: December 21st 2000

Hardcover

266 pages


Description

From Bench to Market: The Evolution of Chemical Synthesis  by  Walter Cabri

From Bench to Market: The Evolution of Chemical Synthesis by Walter Cabri
December 21st 2000 | Hardcover | PDF, EPUB, FB2, DjVu, talking book, mp3, ZIP | 266 pages | ISBN: 9780198503842 | 6.61 Mb

Who wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? Walter Cabri and Romano Di FabioMoreWho wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? Walter Cabri and Romano Di Fabio chart the process of industrial chemical synthesis, from the first discovery of a molecule, or new chemical entity, to its entry in the marketplace as a drug.

They discuss all aspects related to the process research for bulk production, including comparison between different synthetic routes, key methodologies and reaction mechanisms, costs, patent competition, and crystalline forms. The authors use the real chemical history of the development of drugs from several therapeutic areas as detailed case studies, each chosen to illustrate a range of issues and methodologies in industrial chemistry.

Several chapters cover the development of the various b-lactam antibiotics- two chapters describe the discovery and synthesis of the anticancer drugs Idarubicin and Paclitaxal- in another chapter, the synthesis of the anti-viral drug Acyclovir and the patent war that resulted are explored.



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